Background: Gastric intestinal metaplasia (IM) is generally considered as a precancerous condition, a related risk\nfactor for intestinal-type gastric cancer. However, an accurate endoscopic diagnosis of IM is a clinical challenge.\nConfocal Laser Endomicroscopy (CLE) is a newly technique that can provide real-time magnified images and\nvisualize tissues at cellular or subcellular levels. The aim of this study is to clarify the diagnostic value of CLE in\ndetection of IM in patients at high risk of gastric cancer.\nMethods: Systematic literature searches up to April 2015 in PubMed, Embase, Web of Science, Cochrane Library\ndatabases were conducted by two reviewers independently. The Quality Assessment of Diagnostic Accuracy\nStudies-2 (QUADAS-2) tool was applied to assess study quality and to reduce potential bias. A meta-analysis using\nMeta-Disc (version 1.4) and STATA software (version 13) was performed.\nResults: A total of four studies enrolled 218 patients and 579 lesions were included in this meta-analysis. On per-lesion\nbasis, the pooled sensitivity and specificity of CLE were 0.97(95 % confidence interval (CI) = 0.94ââ?¬â??0.98) and 0.94\n(95 % CI = 0.91ââ?¬â??0.97) respectively. The pooled positive likelihood ratio (PLR) and negative likelihood ratio (NLR)\nwere 15.20 (95 % CI = 9.46ââ?¬â??24.41) and 0.04 (95 % CI = 0.02ââ?¬â??0.07) respectively. The pooled diagnostic odds ratio (DOR)\nwas 479.59 (95 % CI = 205.64ââ?¬â??1118.51) and summary receiver operating curve (SROC) area under the curve was 0.9884.\nThere was no statistical significance of publication bias.\nConclusion: CLE is a promising endoscopic tool in the detection of IM with the relatively high diagnostic value in\npatients at high risk of gastric cancer
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